This presentation will review multimodal interdisciplinary strategies with the goal of transforming scientific knowledge into meaningful clinical practice and ultimately providing for “Precision or Personalized TBI Management” . A comprehensive overview of the latest relevant basic science and clinical research following TBI will be presented. We aim for attendees to better understand barriers to knowledge translation following TBI and how to best design research that is easily understandable, implementable and relevant to those patients and families served. Real time multidisciplinary efforts with collaborative public and private partnerships are rapidly advancing our scientific research as a basis for implementing best evidence informed clinical practices and future directions will be reviewed.