While the pathophysiology of mild TBI has been described as a “Neurometabolic Cascade of Concussion” it is increasingly evident that this post-injury biology is limited neither to neurons nor metabolism. This talk will extend the previous understanding of post-concussion pathophysiology to include non-neuronal cell types, and beyond purely metabolic changes. At the end of this presentation, participants will 1) understand contributions of astrocytes, microglia, endothelia and oligodendrocytes to post-concussion biology, in addition to neurons, 2) identify both metabolic and non-metabolic post-injury pathophysiology, including changes in synaptic plasticity, white matter myelin, neurovascular unit and glymphatic flow.

The most recent International Consensus Conference on Concussion in Sport was held in Amsterdam in 2022. New evidence-based guidelines have emerged since the last conference held in Berlin in 2016 that will impact concussion care worldwide. At the end of this presentation, learners will be able to describe: (1) Updates to the diagnosis, assessment and management of Sport-related concussion (SRC); (2) Strategies for helping return concussed athletes to school; and (3) Strategies for helping return concussed athletes to sport.

The Predicting Persistent Post-concussive Problems in Pediatrics (5P Study) derived and validated a clinical prediction rule to stratify risk of symptom persistence following concussion; attendees of this workshop learn how to implement the 5P score into clinical practice. The session will discuss how symptoms cluster across physical, cognitive, sleep and emotional domains and how these can inform clinical phenotypes. Participants will gain a deeper understanding of how clinical phenotyping can inform personalized treatment approaches and appreciate the potential for precision medicine to optimize post-concussion recovery.