TBI is a complex process with a multitude of mechanical and biological components. Post-TBI neurobiology is linked to early clinical signs and symptoms as well as later recovery and persisting sequelae. This talk will illustrate how a more biologically complete understanding of TBI will improve TBI classification and identify actionable targets for treatment and rehabilitation.

In this session, we will discuss the 2018 United States and 2020 European Guidelines regarding the optimal clinical management of patients with severe traumatic brain injury and disorders of consciousness. We will consider the emerging role of advanced neurotechnologies, such as task-based functional MRI and EEG, in the diagnostic and prognostic assessment. We will also discuss current best practices for pharmacologic therapy to promote recovery of consciousness.