After “mild” traumatic brain injury/concussion in civilians and military service members, the severity of depressive symptoms is among the strongest correlates of overall outcomes. We and others have shown that people with substantial depressive symptoms after TBI have different brain functional connectivity patterns on resting state fMRI than people with major depressive disorder or TBI without substantial depressive symptoms. In this session, we will introduce individual subject resting state fMRI brain functional connectivity mapping, and then describe the use of this mapping technique to guide transcranial magnetic stimulation treatment. Pilot clinical trial results will be presented, along with an update on our ongoing multicenter double blinded randomized controlled trial.