Persisting symptoms after concussion/mTBI are not a single “post-concussion syndrome”. There is an emerging differential diagnostic and evidence-based treatment approach that all clinicians should be aware of and employing in their practices. At the conclusion of this activity, participants will be able to: (1) Describe the differential diagnosis of Persisting Post-concussive Symptoms (PPCS); and (2) Describe the treatment for the various symptom generators of PPCS.