Professional experience informs clinical practice. However, exploratory laboratory studies, using relevant models of the human condition, drive innovation in clinical care and neurorehabilitation. Although specific pharmacological treatments have not translated from experimental models to the clinic, the resultant insights, knowledge, and perspectives empower clinical providers to make informed decisions with their patients regarding diagnosis, prognosis, and treatment of TBI. The presentation will discuss investigations that delivered evidence to advance TBI clinical care and neurorehabilitation.